What medicine should you not take if you have high uric acid?
In recent years, high uric acid has become a health problem that plagues many people. High uric acid may not only cause gout, but is also closely related to chronic diseases such as cardiovascular disease and diabetes. In addition to dietary control, drug selection is also something that patients with high uric acid need to pay special attention to. This article will combine the hot topics and hot content on the Internet in the past 10 days to provide you with a detailed analysis of the drugs that patients with high uric acid should avoid, and provide structured data for reference.
1. The dangers of high uric acid and the effects of drugs

Uric acid is the final product of purine metabolism in the human body and is normally excreted through urine. But when uric acid is produced too much or its excretion is reduced, it can lead to an increase in uric acid. Long-term high uric acid may cause gout, kidney stones, kidney damage and other problems. Certain drugs can interfere with the metabolism or excretion of uric acid, further aggravating the condition.
2. Drugs that patients with high uric acid should avoid
The following is a list of drugs that patients with high uric acid should use with caution or avoid:
| drug class | specific drugs | Influence mechanism |
|---|---|---|
| diuretics | Furosemide, hydrochlorothiazide | Reduce uric acid excretion, leading to increased blood uric acid |
| immunosuppressant | cyclosporine, tacrolimus | Inhibit renal uric acid excretion |
| antituberculosis drugs | pyrazinamide | Interference with uric acid excretion |
| beta blockers | Metoprolol, atenolol | Slightly elevated blood uric acid levels |
| Aspirin | low dose aspirin | Inhibit uric acid excretion |
| Niacin | Vitamin B3 | Increase uric acid production |
3. Suggestions on Alternative Drug Selection
For patients who must use the above drugs, alternatives can be chosen under the guidance of a doctor:
| original drug | alternative | Remarks |
|---|---|---|
| Furosemide | Losartan | Has both antihypertensive and uric acid excretion effects |
| hydrochlorothiazide | Indapamide | Less impact on uric acid |
| low dose aspirin | clopidogrel | Antiplatelets do not increase uric acid |
4. Hot topics related to the entire network in the past 10 days
According to data monitoring across the entire network, recent hot discussions about high uric acid mainly focus on the following aspects:
| topic | heat index | main focus |
|---|---|---|
| The relationship between high uric acid and antihypertensive drugs | 85 | How do patients with hypertension choose drugs that do not affect uric acid? |
| Drugs for acute gout attacks | 78 | When to use colchicine and NSAIDs |
| Progress of new uric acid-lowering drugs | 65 | Clinical effects of new URAT1 inhibitors |
| The relationship between diet and uric acid | 92 | High Purine Food List Update |
5. Daily management suggestions
1.Regular monitoring: Patients with high uric acid should check their blood uric acid levels every 3-6 months
2.Rational use of medication: Use benzbromarone, allopurinol and other uric acid-lowering drugs under the guidance of a doctor
3.lifestyle adjustments: Control weight, limit alcohol intake, drink more water
4.Drug use notification: Take the initiative to inform the doctor about your history of high uric acid when seeking medical treatment
6. Special reminder
The drug information listed in this article is for reference only, and the specific medication plan must be formulated by a professional doctor based on the patient's individual conditions. Patients with high uric acid should not adjust or stop taking their medications on their own to avoid health risks. If gout symptoms such as joint swelling and pain occur, seek medical attention promptly.
By understanding the relationship between these drugs and uric acid, patients with high uric acid can better communicate with their doctors, develop personalized treatment plans, and avoid aggravation of the condition due to inappropriate medication. Remember, scientific medication is a key part of controlling high uric acid.
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